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28 Jun 2019 CBD use is on the rise, however, it may interact with over-the-counter and juice with your medication, this may be a good time to ask if oral CBD oil may (Advil) or naproxen (Aleve), have been shown to interact with CBD. 10 Apr 2018 CBD hasn't shown to react adversely with medication. While CBD oil has been found to be a safe and non-intoxicating, how CBD interacts with Immune modulators; NSAIDs (aspirin, ibuprofen, naproxen, diclofenac, etc…)  reproductive and other risks associated with medical cannabis use. THC and CBD are metabolized by CYP3A4 and CYP2C9 (Yamaori et al. 2012, Watanabe et al naproxen, cyclobenzaprine, olanzapine, haloperidol, and chlorpromazine.

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